To get the grub bootloader to ignore a driver as an option to boot from use the GRUB_OS_PROBER_SKIP_LIST option in /etc/default/grub.
example
GRUB_OS_PROBER_SKIP_LIST="48cb3fae-2c22-47c6-bfc7-799572ce14b7@/dev/mapper/root-drive
use the “blkid” command to get the UUID